Overview:
The Mancias Lab studies critical aspects of the biology of pancreatic cancer to develop novel therapeutic approaches. Areas of emphasis are on the role of selective autophagy and iron metabolism in pancreatic cancer molecular pathogenesis (Mancias et al., Nature 2014; Mancias et al., eLife 2015; Santana-Codina et al., Cancer Discovery 2022). We are also interested in identifying the biochemical pathways and signaling networks that mediate pancreatic cancer treatment resistance, including to targeted inhibitors (e.g. oncogenic KRAS inhibitors, immunotherapy and radiotherapy (Biancur et al., Nature Communications 2017; Santana-Codina et al., Cell Reports 2020).
The lab takes a comprehensive approach to study our questions combining biochemical, quantitative mass spectrometry-based proteomics, CRISPR genetic screens (in vitro and in vivo), cell biological, and mouse modeling techniques.
For more information on the lab, please visit here: https://manciaslab.dana-farber.org and here: https://twitter.com/ManciasLab .
The Scientist I will be part of a rich intellectual and collaborative environment and will have access to state-of-the-art facilities within the laboratory, the Dana-Farber Cancer Institute, Harvard Medical School, and other top academic institutions across the Boston Area. Importantly, we are part of a Pancreatic Cancer Research Collective, the Hale Family Pancreatic Cancer Research Center at Dana-Farber that brings together investigators from a wide variety of backgrounds for collaborative projects on pancreatic cancer. For more information on the Hale Center, please see here: https://halecenter.dfci.harvard.edu/
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
Responsibilities:
The candidate will perform high-throughput, multi-omics profiling to identify therapeutic targets in pancreatic cancer, resistance mechanisms to KRAS inhibition, and biomarkers of resistance. In addition, the candidate will leverage bioinformatics expertise (R, Python, GSEA, Reactome, Skyline, MSFragger) to evaluate complex datasets (unpublished, already available in the lab) to identify actionable targets for pancreatic cancer therapeutic development.
Qualifications:
* PhD. or equivalent degree in Molecular and Cellular Biology, with a minimum of 4 years of postdoctoral experience preferred. Industry experience is a plus.
* Demonstrated leadership and mentorship skills.
* Strong communication skills, with experience in preparing manuscripts, patents, and grant applications and presenting research findings at scientific meetings.
At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.
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